ABSTRACT
Objective: In the present study, the association between red cell distribution width [RDW] with functional significance of intermediate coronary artery lesions was investigated
Materials and Methods: Two hundred and forty-six consecutive patients, 168 males and 78 females, who underwent fractional flow reserve [FFR] measurement for angiographically intermediate coronary stenosis [40-70% in quantitative coronary analysis] in the left anterior descending coronary artery were enrolled into the study. The functional significance of intermediate coronary artery lesions was determined by FFR measurement. An FFR value <0.75 was defined as functionally significant. Venous blood samples were taken within 48 h before the FFR measurement, and RDW levels were determined by a Coulter LH Series hematology analyzer. Logistic regression analysis was used to examine the association between functional significance in FFR measurement and other variables
Results: Of the 246 patients, 62 [25.2%] exhibited significant functional stenosis [FFR <0.75] in the FFR measurement. The mean RDW level was significantly higher in patients with significant stenosis [14.19 +/- 0.73 vs. 13.69 +/- 0.77, p < 0.001]. In stepwise multivariate logistic regression analysis, RDW [OR = 2.489, 95% CI = 1.631-3.799, p < 0.001] and male gender [OR = 2.826, 95% CI = 1.347-5.928, p = 0.006] were independent predictors of significant functional stenosis
Conclusion: Increased RDW levels were associated with functional significance of angiographically intermediate coronary artery stenoses